ࡱ;   !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~Root Entry  \pCalc Ba=@  =@ 8X@"1Calibri1Arial1Arial1Arial1Calibri General #,##03._(\$* #,##0_);_(\$* \(#,##0\);_(\$* \-_);_(@_)\(#,##0_);[RED]\(#,##0\)!"($"#,##0_);[RED]"($"#,##0\)'""($"#,##0.00_);[RED]"($"#,##0.00\) #,##0.00;6_(\$* #,##0.00_);_(\$* \(#,##0.00\);_(\$* \-??_);_(@_)                + ) , *   ( "8 "8  #8 #4  $  $  $  $  (  $   (8  $  $ `"ZIcommission file number 001Mtable of contents"Xcomparison of the years en"dresearch and development e"kgeneral and administrativer cash flows#wconsolidated balance sheets‰ operations cash flows-1"Fredeemable convertible pre H3 property and equipment!4 fair value measurements#&4 fair value measurements-1#4 fair value measurements-2"45 accrued expenses and oth6 debt financingterminal interest fee 7 stockholders equitystock option valuation &stock option valuation-1 %stock option valuation-2*8 income taxes18 income taxes-1"99 commitments and contingeZ=11 net loss per shareC11 net loss per share-1HexhibitsP exhibit 211"RVcertification of principal$Ycertification of principal-1"*]section 906 of the sarbane$z`section 906 of the sarbane-1TRJ!       3  @@   0!COMMISSION FILE NUMBER 001-38501Delaware 26-3321056>(State or other jurisdiction of incorporation or organization)$(I.R.S. Employer Identification No.)R840 Memorial DriveCambridge, Massachusetts(Address of principal executive offices)02139(Zip Code)B(857) 320-2200(Registrant s telephone number, including area code)TABLE OF CONTENTSPagePART IItem 1. BusinessItem 1A. Risk Factors"Item 1B. Unresolved Staff CommentsItem 2. PropertiesItem 3. Legal ProceedingsItem 4. Mine Safety DisclosuresPART IItItem 5. Market for Registrant s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity SecuritiesItem 6. Selected Financial Data]Item7.Management s Discussion and Analysis of Financial Condition and Results of OperationsCItem 7A.Quantitative and Qualitative Disclosures about Market Risk3Item 8. Financial Statements and Supplementary Data\Item 9.Changes in and Disagreements with Accountants on Accounting and Financial Disclosure Item 9A.Controls and ProceduresItem 9B.Other InformationPART III?Item 10.Directors, Executive Officers and Corporate GovernanceItem 11.Executive CompensationgItem 12.Security Ownership of Certain Beneficial Owners and Management and Related Stockholder MattersQItem 13.Certain Relationships and Related Transactions and Director Independence/Item 14.Principal Accountant Fees and ServicesPART IV3Item 15. Exhibits and Financial Statement SchedulesItem 16. Form 10-K Summary SIGNATURES8Comparison of the Years Ended December 31, 2019 and 2018Year Ended December 31,20192018ChangeOperating expenses:Research and developmentGeneral and administrativeTotal operating expensesLoss from operationsOther income (expense):Interest income Other income9Change in fair value of preferred stock warrant liabilityInterest expense!Total other income (expense), netNet loss!Research and Development ExpensesSalary and benefits-related Stock-based compensation expense&Clinical research and outside servicesFacility related and other'Total research and development expenses#General and Administrative Expenses)Other contract services and outside costs)Total general and administrative expenses Cash Flows%Net cash used in operating activities%Net cash used in investing activities)Net cash provided by financing activities)Net increase in cash and cash equivalentsConsolidated Balance Sheets December 31AssetsCurrent assets:Cash and cash equivalents)Prepaid expenses and other current assetsTotal current assetsProperty and equipment, net"Security deposits and other assetsDeferred offering costs Total assetsVLiabilities, Redeemable Convertible Preferred Stock and Stockholders' Equity (Deficit)Current liabilities:Accounts payable.Accrued expenses and other current liabilitiesTotal current liabilitiesLong term debt, net of discountOther liabilities!Preferred stock warrant liabilityTotal liabilities&Commitments and contingencies (Note9)/Redeemable convertible preferred stock (Note7)Stockholders' equity (deficit):Preferred stock, $0.001 par value; 10,000,000 shares authorized and no shares issued or outstanding as of December 31, 2019; No shares authorized, issued or outstanding at December 31, 2018Common stock, $0.001 par value; 150,000,000 and 47,000,000 shares authorized, 23,607,797 and 5,193,915 shares issued and 23,188,816 and 4,774,934 shares outstanding at December 31, 2019 and 2018, respectivelyAdditional paid-in capital&Treasury stock, 418,981 shares at costAccumulated deficit$Total stockholders' equity (deficit)\Total liabilities, redeemable convertible preferred stock and stockholders' equity (deficit)%Consolidated Statements of Operations%Net loss per share, basic and diluted=Weighted average common shares outstanding, basic and diluted%Consolidated Statements of Cash Flows%Cash flows from operating activities:JAdjustment to reconcile net loss to net cash used in operating activities:Depreciation and amortizationNon-cash interest expense&Gain on sale of property and equipment,Changes in operating assets and liabilities:Other long-term assets%Cash flows from investing activities:#Purchases of property and equipment0Proceeds from the sale of property and equipment%Cash flows from financing activities:"Payment of deferred offering costs<Proceeds from initial public offering, net of issuance costsLProceeds from issuance of preferred convertible stock, net of issuance costs(Proceeds from issuance of long term debtPayment of debt issuance costs!Payment of success fee obligation.Proceeds from exercise of common stock options,Cash and cash equivalents, beginning of year&Cash and cash equivalents, end of year#Supplemental cash flow information:Cash paid for interestIDeferred offering costs included in accounts payable and accrued expenses$ UPurchases of property and equipment included in accounts payable and accrued expensesGSupplemental disclosure of non-cash investing and financing activities::Reclassification of warrants to additional paid-in capitalYConversion of preferred stock to common stock upon closing of the initial public offering0Accretion of preferred stock to redemption valuedConsolidated Statements of Redeemable Convertible Preferred Stock and Stockholders' Equity (Deficit)&Redeemable convertible preferred stock Common stockAdditional paid-in capitalTreasury stock$Total stockholders equity (deficit)SharesAmount Par ValueBALANCE - January 1, 2018ZIssuance of Series E redeemable convertible preferred stock, net of issuance costs of $139 Exercise of common stock optionsStock-based compensationBALANCE - December 31, 20189Issuance of common stock, net of issuance costs of $6,896 Exercise of common stock warrantBALANCE - December 31, 20193. PROPERTY AND EQUIPMENT December 31,Laboratory equipmentLeasehold improvementsOffice and computer equipmentFurniture and fixturesProperty and equipment, gross/Less: accumulated depreciation and amortization4. FAIR VALUE MEASUREMENTS3Fair value measurements at December 31, 2019 using:Level 1Level 2Level3TotalAssets:Cash equivalents4Fair value measurements at December 31, 2018 using:Level1Level2 Liabilities:Success fee liability Success fee#Preferred stock warrant liabilityBalance  January 1, 20185Increase in success fee included in other liabilities8Increase in warrant fair value included in other expenseBalance  January 1, 2019EReclassification to additional paid-in capital in connection with IPOPayment of success feeBalance  December 31, 201925. ACCRUED EXPENSES AND OTHER CURRENT LIABILITIES *Accrued employee compensation and benefits2Accrued external research and development expensesAccrued professional feesOther4Total accrued expenses and other current liabilities6. DEBT FINANCING"Principal amount of long term debt Debt discountDeferred financing feesTerminal Interest FeeYear Ending December 31,20202021202220237. STOCKHOLDERS' EQUITYDecember 31, 2018Preferred Stock Authorized&Preferred Stock Issued and OutstandingCarrying ValueLiquidation Preference%Common stock issuable upon conversionSeriesA preferred stockSeriesB preferred stockSeriesB-1 preferred stockSeriesC preferred stockSeriesD preferred stockSeriesE preferred stockStock Option ValuationRisk-free interest rate2.09% 1.93% - 3.02%Expected option life (in years) 0.25 - 6.25Expected dividend yield0%Expected volati<lity71%65%OptionsWeighted Average Exercise Price*Weighted Average Remaining Life (in Years)Intrinsic Value (in thousands)!Outstanding as of January1, 2019Granted ExercisedCanceled#Outstanding as of December 31, 2019#Exercisable as of December 31, 20192Vested or expected to vest as of December 31, 20198. INCOME TAXESTax at U.S. statutory rate21.0%#State taxes, net of federal benefit6.0%6.2%Permanent differences(1.9)%(1.5)% Tax credits4.1%3.8%Change in valuation allowance(29.2)%(29.5)%Effective income tax rate0.0 % Net operating loss carryforwards1Research and development tax credit carryforwardsStart-up costs*Capitalized research and development costs DepreciationAccrued expenses Other itemsTotal deferred tax assetsValuation allowanceNet deferred tax asset!9. COMMITMENTS AND CONTINGENCIESYears Ending December 31,11. NET LOSS PER SHARE Numerator:3Accretion of redeemable convertible preferred stock,Net loss attributable to common stockholders Denominator:ERedeemable convertible preferred stock (as converted to common stock)ZWarrants to purchase redeemable convertible preferred stock (as converted to common stock)Outstanding stock optionsExhibits ExhibitNo. Exhibit IndexRestated Certificate of Incorporation of the Registrant (Incorporated by reference to Exhibit 3.3 to the Registrant s Current Report on Form 8-K (File No. 001-38901) filed with the Securities and Exchange Commission on May 13, 2019).Amended and Restated Bylaws of Registrant (Incorporated by reference to Exhibit 3.4 to the Registrant s Current Report on Form 8-K (File No. 001-38901) filed with the Securities and Exchange Commission on May 13, 2019).Specimen Stock Certificate evidencing shares of common stock (Incorporated by reference to Exhibit 4.1 to the Registrant s Amendment No. 1 to the Registration Statement on Form S-1/A (File No. 333-230822) filed with the Securities and Exchange Commission on April 30, 2019).AFifth Amended and Restated Investors' Rights Agreement among the Registrant and certain of its stockholders, dated November30, 2018 (Incorporated by reference to Exhibit 4.2 to the Registrant s Registration Statement on Form S-1 (File No. 333-230822) filed with the Securities and Exchange Commission on April 12, 2019).4.3**Description of the Registrant s Securities10.1#2010 Stock Incentive Plan, as amended (incorporated by reference to Exhibit 10.1 to the Registrant s Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333-230822) filed with the Securities and Exchange Commission on April 30, 2019).10.2#2019 Stock Option and Incentive Plan and forms of award agreements thereunder (incorporated by reference to Exhibit 10.2 to the Registrant s Amendment No. 2 to the Registration Statement on Form S-1 (File No. 333-230822) filed with the Securities and Exchange Commission on May 6, 2019).10.3#2019 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.3 to the Registrant s Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333-230822) filed with the Securities and Exchange Commission on April 30, 2019).10.4#Senior Executive Cash Incentive Bonus Plan (incorporated by reference to Exhibit 10.4 to the Registrant s Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333-230822) filed with the Securities and Exchange Commission on April 30, 2019).10.5#?Amended and Restated Employment Agreement between the Registrant and William Hinshaw, dated December 20, 2018 (incorporated by reference to Exhibit 10.5 to the Registrant s Amendment No. 2 to the Registration Statement on Form S-1 (File No. 333-230822) filed with the Securities and Exchange Commission on May 6, 2019). Exhibit 21.1List of Subsidiaries Subsidiary-Jurisdiction of incorporation or organizationAcora Nutrition LLC%Axcella Health Securities Corporation Massachusetts,CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICERDate: March 23, 2020By:/s/ William R. Hinshaw, Jr.William R. Hinshaw, Jr. President, Chief Executive Officer and Director(Principal Executive Officer),CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER/s/ Laurent ChardonnetFLaurent ChardonnetChief Financial Officer(Principal Financial Officer)-SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002!William R. 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