аЯрЁБс;ўџ  ўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџ§џџџџџџџ ўџџџўџџџўџџџ!ўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџRoot Entryџџџџџџџџџџџџўџџџџџџџџџџџџџџџўџџџџџџџџџџџџџџџўџџџџџџџџџџџџџџџўџџџ Л ЬсАСт\pCalc BАaР= œЏМ=@ 8X@"Зк1мCalibri1ШџArial1ШџArial1ШџArial1мМCalibri1мCalibri ЄGeneral Ѕ#,##0.00 І#,##03Ї._(\$* #,##0_);_(\$* \(#,##0\);_(\$* \-_);_(@_)Ј\(#,##0_);[RED]\(#,##0\);Љ6_(\$* #,##0.00_);_(\$* \(#,##0.00\);_(\$* \-??_);_(@_)рЄѕџ Р рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рЄ Р р+ѕџ №Р р)ѕџ №Р р,ѕџ №Р р*ѕџ №Р р ѕџ №Р рЄ (Р рЄ"8Р рЄ*Р рЄ(Р рЄ (Р рЅ Р рЄ(Р рІ Р рЄ(Р рЄ"0Р рЄ"8Р рЄ(8Р рЄ"Р рЄ*8Р рЇ"Р рІ"Р рЈ"Р рЉ"Р рЄ(8Р “€џ“€џ“€џ“€џ“€џ“€џ`… epstein david r…, epstein david r-1…z)epstein david r-2…-epstein david r-3…b2epstein david r-4ŒССTыz№r№83 №П Р@@ё  їќв”REpstein David RFORM 4єUNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940WOMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5 OMB APPROVALHOMB Number: 3235-0287 Estimated average burden hours per response: 0.5 OMB Number: 3235-0287Estimated average burdenhours per response:‡Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).Д1. Name and Address of Reporting Person*Epstein David R (Last) (First) (Middle) C/O AXCELLA HEALTH INC. 840 MEMORIAL DRIVE (Street) CAMBRIDGE MA 02139 (City) (State) (Zip)(Last)(First)(Middle)C/O AXCELLA HEALTH INC.840 MEMORIAL DRIVE CAMBRIDGEMA(City)(State)(Zip)T2. Issuer Name and Ticker or Trading Symbol Axcella Health Inc. [ AXLA ]š5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X Director 10% Owner Officer (give title below) Other (specify below)XDirector 10% OwnerOfficer (give title below)Other (specify below)D3. Date of Earliest Transaction (Month/Day/Year) 06/05/2020A4. If Amendment, Date of Original Filed (Month/Day/Year)˜6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person"Form filed by One Reporting Person,Form filed by More than One Reporting PersonPTable I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned&1. Title of Security (Instr. 3)*2. Transaction Date (Month/Day/Year)82A. Deemed Execution Date, if any (Month/Day/Year)%3. Transaction Code (Instr. 8)H4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)k5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)?6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)<7. Nature of Indirect Beneficial Ownership (Instr. 4)CodeVAmount (A) or (D)PriceŒTable II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)11. Title of Derivative Security (Instr. 3)62. Conversion or Exercise Price of Derivative Security*3. Transaction Date (Month/Day/Year)83A. Deemed Execution Date, if any (Month/Day/Year)%4. Transaction Code (Instr. 8)d5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)?6. Date Exercisable and Expiration Date (Month/Day/Year)X7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)18. Price of Derivative Security (Instr. 5)p9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)@10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)=11. Nature of Indirect Beneficial Ownership (Instr. 4)(A)(D)Date ExercisableExpiration DateTitleAmount or Number of SharesStock Option (Right to Buy) 06/05/2020A 06/04/2030 Common StockD-By: /s/ Heidy King-Jones, as Attorney-in-Fact 06/08/2020 ** Signature of Reporting PersonDatekReminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.Ÿ* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).Љ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).ЌNote: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.žPersons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.џ RЋ cc Л Ь d-Cыт6?_€%,С*+‚ƒ„&ffffffц?'ffffffц?(ш?)ш?Ё"d,, Ж` Ж`р? 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